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Retroperitoneal leiomyosarcoma, a malignant neoplasm with smooth muscle differentiation, seldom metastasize. The gastrointestinal tract is rare site of metastases, and diffuse polypoidal involvement is an uncommon presentation. Case Report: A 61-year-old male diagnosed with retroperitoneal leiomyosarcoma underwent surgical resection of the tumor along with chemotherapy and radiation. He presented with 2 months history of vomiting, and melena. Upper gastrointestinal (GI) endoscopy, capsuledoi:10.17659/01.2020.0068 fatcat:5yvyrtre2jcaxlkbjdncchgx7u