A total of 120 one day old Japanese quail chicks were used in this experiment. During the first two weeks, all chicks were fed a diet formulated to meet the recommended requirements for the growing quails. Thereafter, chicks were randomly classified into three equal groups (each of 40 chicks). The first and second groups, the treated groups were fed on the basal diet, supplemented with 3.3 and 6.6 mg/ kg /diet of a mixture, containing some chemical drugs i.e. Clidinum, Almitrine, Raubasine and

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... razodone (CART), while the third group received only the basal diet whithout any addition (control). At four and six weeks post of groups, five quails from each of groups were randomly chosen and slaughtered. Plasma samples were collected and frozen until biochemical analysis. Liver and brain were frozen until estrases enzymes activities were determined. The achieved results indicated that body weight, feed consumption and feed efficiency and relative weight of some organs and plasma Cholinestrase activity during both of the two experimental periods of feeding have not been significantly affected by the CART supplementation. Lipogenic activity in liver slices (in vitro) was significantly affected by 6.6 mg CART and relatively by other groups, (9.33%) (control and 3.3 mg CART). Feeding CART increased liver ChE activity especially in quails that fed on 6.6 mg than the other groups (47.7%) . Also, age of birds had a significant effect on liver fat content (3.7%). Brain AChE activity increased significantly especially in quails fed on 3.3 mg CART than other groups (22%). The CART feeding especially at the level of 3.3 mg increased unsaturated than saturated fatty acid in the liver fat. This study revealed that diets supplemented with CART possessed the ability to control the appetite center through different ways in regulating feeding intake and growth in quail birds.