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High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver
2016
Epigenetics
High-fat diet consumption and sedentary lifestyle elevates risk for obesity, non-alcoholic fatty liver disease, and cancer. Exercise training conveys health benefits in populations with or without these chronic conditions. Diet and exercise regulate gene expression by mediating epigenetic mechanisms in many tissues; however, such effects are poorly documented in the liver, a central metabolic organ. To dissect the consequences of diet and exercise on the liver epigenome, we measured DNA
doi:10.1080/15592294.2016.1261239
pmid:27858497
pmcid:PMC5270632
fatcat:qdhe4bq3ybhihestv44u2kt73i