Comparison of Regional Gray Matter Atrophy, White Matter Alteration, and Glucose Metabolism as a Predictor of the Conversion to Alzheimer's Disease in Mild Cognitive Impairment

Bo Kyung Sohn, Dahyun Yi, Eun Hyun Seo, Young Min Choe, Jee Wook Kim, Shin Gyeom Kim, Hyo Jung Choi, Min Soo Byun, Jin Hyeong Jhoo, Jong Inn Woo, Dong Young Lee
<span title="">2015</span> <i title="Korean Academy of Medical Sciences (KAMJE)"> <a target="_blank" rel="noopener" href="" style="color: black;">Journal of Korean medical science</a> </i> &nbsp;
We compared the predictive ability of the various neuroimaging tools and determined the most cost-effective, non-invasive Alzheimer's disease (AD) prediction model in mild cognitive impairment (MCI) individuals. Thirty-two MCI subjects were evaluated at baseline with [ 18 F]-fluorodeoxyglucose positron emission tomography (FDG-PET), MRI, diffusion tensor imaging (DTI), and neuropsychological tests, and then followed up for 2 yr. After a follow up period, 12 MCI subjects converted to AD (MCIc)
more &raquo; ... d 20 did not (MCInc). Of the voxel-based statistical comparisons of baseline neuroimaging data, the MCIc showed reduced cerebral glucose metabolism (CMgl) in the temporo-parietal, posterior cingulate, precuneus, and frontal regions, and gray matter (GM) density in multiple cortical areas including the frontal, temporal and parietal regions compared to the MCInc, whereas regional fractional anisotropy derived from DTI were not significantly different between the two groups. The MCIc also had lower Mini-Mental State Examination (MMSE) score than the MCInc. Through a series of model selection steps, the MMSE combined with CMgl model was selected as a final model (classification accuracy 93.8%). In conclusion, the combination of MMSE with regional CMgl measurement based on FDG-PET is probably the most efficient, non-invasive method to predict AD in MCI individuals after a two-year follow-up period.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.3346/jkms.2015.30.6.779</a> <a target="_blank" rel="external noopener" href="">pmid:26028932</a> <a target="_blank" rel="external noopener" href="">pmcid:PMC4444480</a> <a target="_blank" rel="external noopener" href="">fatcat:i2hi4phpjndghp7opt6q3movfm</a> </span>
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