Two field experiments were conducted during 2013 / 2014 and 2014 / 2015 seasons at Sakha Agriculture Research Station, Egypt to investigate the efficacy of some herbicides i.e. glyphosate and propyzamide in addition to the hand pulling for controlling dodder weed (Cuscuta planiflora ten.) and their effects on some growth characters, seed yield of clover plants (Trifolium alexandrinum L.) and herbicide residues in the soil and clover plants. Results indicated that glyphosate at the rates of 0.07

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... and 0.1 l/fed showed excellent control of dodder with 97.7 and 98.9 % control, followed by Propyzamide at the rate 0.75 and 1.0 l/fed with 83.0 and 88.0% control, respectively. Dodder infestation caused a great decrease in plant height, fresh, dry weight and seed yield of clover plants. Hand pulling treatment was not enough to control dodder, (51% control at the 3 rd cut). Clover plants infested with dodder showed the lowest chlorophyll a, b and the highest carotene content. Data also, cleared that different herbicide treatments showed least decreased on chlorophyll a, b and the increased carotene content compared to un-infested and un-treated plants. Data also, revealed that herbicide treatments slightly decreased protein content of clover. Gglyphosate treatments increased the number and dry weight of nodules, while propyzamide showed an opposite when compared to un-infested and un-treated plants. The glyphosate residue became undetected in the soil after 40 days from application. At the end of the experiment there were no residue in clover plants. The times for 50% loss of initial propyzamide in soil were 23 and 26 days. The loss of initial concentrations reached (98.91 and 99.1%). At the end of experiment (60 days) there were no propyzamide residues in the clover plants. These results indicated that under heavy invested soil with dodder, it is possible to use each of (glyphosate at 0.07 l/fed or propyzamide at 0.1 l/fed) for dodder weed control. These treatments gave the economically best dodder control and increased clover yield and it's components, without any harm effect on clover plants or on the soil.