A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is
The effect of membrane potential on feedback inhibition of acetylcholine (ACh) release was studied using the frog neuromuscular junction. It was found that membrane potential affects the functional affinity (K i ) of the presynaptic M 2 muscarinic receptor. The K i for muscarine shifts from ϳ0.23 M (at resting potential) to ϳ8 M (at a high depolarization). Measurements of Ca 2ϩ currents in axon terminals showed that the depolarizationmediated shift in K i does not stem fromdoi:10.1523/jneurosci.22-09-03426.2002 pmid:11978819 fatcat:5drbrwxb55evzli6rovvv42nbi