This study extends the capability and increases the performance of a traditional Branch and Bound (BB) algorithm to solve Facility Location-Transportation problems for Disaster Response (FLTDR) using parallel computing. A Two-Stage Branch and Bound (TBB) algorithm was developed to support two parallel computing approaches. This algorithm divides problems into two small sub-problems, which are a facility location sub-problem and a transportation sub-problem. All possible numbers of distribution

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... enters are determined. All possible locations relating to any number of distribution centers are explicitly explored. The transportation sub-problem corresponding to any selected location is then solved. Two parallel approaches for the TBB algorithm (PTBB) differ in partitioning the list of sub-problems. The first approach (PTBB1) solves both sub-problems in parallel. The other (PTBB2) explores the locations in sequence and solves only the transportation sub-problems in parallel. The numerical experiments were conducted on various sizes of generated problems. The quality of the solution and the computing time of both approaches were compared with a BB algorithm with premature termination by time. The experimental experiences showed that both PTBB1 and PTBB2 are more efficient and effective than a BB algorithm. However, the PTBB1 should be suggested for the FLTDR because of the least computational time usage.