Bacterial pathogens analysis in Lethrinus lentjana commercially available fish indicated the presence of two major fish pathogens such as Aeromonassp and Vibrio sp. In this study, the effect of antibiotics, probiotic preparations along with plant extract was investigated against four species coming under two bacterial genus A. hydrophila, A. sobriaand V. cholerae and V. damsela. Test conducted with 20 antibiotics of different types revealed the emergence of Multi Drug Resistance in all the

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... d organisms. Highest % of resistance was noted in A. sobria, V. damsela and least in A. hydrophila, V. cholerae. The resistance was in the following order A. sobria, V. damsela, A. hydrophila, V. cholerae. Ineffective nature of commonly used antibiotics such as Amoxicillin, Ampicillin, Carbenicillin, Ciprofloxacin and Erythromycin against the tested organisms worrying us because which could target not only aquatic animals but also human. Attention on organic aquaculture has been on raise due to the side effects of chemicals. Examination of the effect of selected 10 herbs and 6 species of commonly used probiotic Lactic Acid Bacteria explored the presence of meager antibacterial effect. Further studies will lead to increase the efficacy of the organic inputs and to develop safe and friendly disease managing strategies. Microbial resistance to antibiotics is gaining a lot of attention in the past few years. All over the world, continuous monitoring of antibiotic resistance in microbes have been done against various drugs. Effective treatment depends on the understanding of antimicrobial resistance developed in microbes. Fish bacterial pathogens are not an exceptional for it. Marine fishes are rich of vital nutrients and transported to faraway places due to its demand among consumers. Transportation, handling, storage and distribution pave way for the contamination at higher degree in addition to its natural microflora. Resistance developed in the bacteria causing diseases in fishes could also harm human beings and could supply resistance to other human pathogens.