Multi-species integrative biclustering

Peter Waltman, Thadeous Kacmarczyk, Ashley R Bate, Daniel B Kearns, David J Reiss, Patrick Eichenberger, Richard Bonneau
2010 Genome Biology  
We describe an algorithm, multi-species cMonkey, for the simultaneous biclustering of heterogeneous multiplespecies data collections and apply the algorithm to a group of bacteria containing Bacillus subtilis, Bacillus anthracis, and Listeria monocytogenes. The algorithm reveals evolutionary insights into the surprisingly high degree of conservation of regulatory modules across these three species and allows data and insights from well-studied organisms to complement the analysis of related but less well studied organisms.
doi:10.1186/gb-2010-11-9-r96 pmid:20920250 pmcid:PMC2965388 fatcat:uiwrcsusx5bttmslq2gum43q44