A retrospective analysis of longitudinal changes in bone mineral content in cystic fibrosis

Adela Chirita-Emandi, Sheila Shepherd, Andreas Kyriakou, Jane D. McNeilly, Carol Dryden, Donna Corrigan, Anne Devenny, Syed Faisal Ahmed
2017 Journal of Pediatric Endocrinology & Metabolism (JPEM)  
AbstractBackground:We aimed to describe the longitudinal changes in bone mineral content and influencing factors, in children with cystic fibrosis (CF).Methods:One hundred children (50 females) had dual X-ray absorptiometry (DXA) performed. Of these, 48 and 24 children had two to three scans, respectively over 10 years of follow-up. DXA data were expressed as lumbar spine bone mineral content standard deviation score (LSBMCSDS) adjusted for age, gender, ethnicity and bone area. Markers of
more » ... a. Markers of disease, anthropometry and bone biochemistry were collected retrospectively.Results:Baseline LSBMCSDS was >0.5 SDS in 13% children, between −0.5; 0.5 SDS, in 50% and ≤−0.5 in the remainder. Seventy-eight percent of the children who had baseline LSBMCSDS >−0.5, and 35% of the children with poor baseline (LSBMCSDS<−0.5), showed decreasing values in subsequent assessments. However, mean LS BMC SDS did not show a significant decline in subsequent assessments (−0.51; −0.64; −0.56; p=0.178). Lower forced expiratory volume in 1 s percent (FEV1%) low body mass index standard deviation scores (BMI SDS) and vitamin D were associated with reduction in BMC.Conclusions:Bone mineral content as assessed by DXA is sub-optimal and decreases with time in most children with CF and this study has highlighted parameters that can be addressed to improve bone health.
doi:10.1515/jpem-2016-0057 pmid:28222031 fatcat:kjermj2hzvhllp66rgnnxryj24