The Healing Effects of Autologous Platelet Gel on Acute Human Skin Wounds

David B. Hom, Bradley M. Linzie, Trevor C. Huang
2007 Archives of Facial Plastic Surgery  
Objective: To compare the healing of full-thickness skin punch wounds treated with topical autologous platelet gel (APG) vs conventional therapy (antibiotic ointment and/or occlusive dressings) in healthy volunteers. Methods: A prospective, single-blind, pilot study comprising 80 full-thickness skin punch wounds (4 mm diameter) was conducted on the thighs of 8 healthy volunteers. With each subject serving as his or her own control (5 punch sites per leg), APG was applied topically on one thigh,
more » ... cally on one thigh, and an antibiotic ointment and/or a semiocclusive dressing was applied on the other thigh. Healing was monitored for spontaneous wound closure by clinical assessment and by digital photographs over 6 months. Over 35 days, 64 serial dermal biopsy specimens (6 mm diameter) were analyzed (using hematoxylineosin, Mason trichrome, CD-34, and Ki-67 stains) to measure differences between treated and control sites for cellularity, granulation formation, vascularity, epithelialization, and cellular replication.
doi:10.1001/archfaci.9.3.174 pmid:17519207 fatcat:hoxigxj4cbd3jhq3hxsaz2ihbu