Plasmid-Controlled Variation in the Content of Methylated Bases in Bacteriophage Lambda Deoxyribonucleic Acid

Stanley Hattman
1972 Journal of Virology  
The N6-methyladenine (MeAde) and 5-methylcytosine (MeG) contents in deoxyribonucleic acid (DNA) of bacteriophage lambda has been analyzed as a function of host specificity. The following facts have emerged: (i) lambda grown on strains harboring the PI prophage contain ca. 70 more MeAde residues/DNA molecule than lambda grown either in the Pl-sensitive parent, or in a P1 immune-defective lysogen which does not confer PI modification; (ii) lambda grown on strains harboring the N-3 drug-resistance
more » ... N-3 drug-resistance factor contain ca. 60 more MeC residues/DNA molecule than lambda grown on the parental strain lacking the factor; (iii) lambda grown in on May 9, 2020 by guest
doi:10.1128/jvi.10.3.356-361.1972 fatcat:fhlqpvze6veh5ek7iv57rvjbwi