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Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release
[article]
2019
bioRxiv
pre-print
AbstractSynaptotagmin1 (Syt1) synchronises neurotransmitter release to action potentials acting as the fast Ca2+ release sensor and as the inhibitor (clamp) of spontaneous and delayed asynchronous release. Whilst the Syt1 Ca2+ activation mechanism has been well characterised, how Syt1 clamps transmitter release remains enigmatic. Here we show that C2B domain-dependent oligomerisation provides the molecular basis for the Syt1 clamping function. This follows from the investigation of a designed
doi:10.1101/594051
fatcat:blsgt6j6zfepnebglrmqv2t74y