Systemic lupus erythematosus is a systemic disease that can lead to lupus nephritis, as one of the most dangerous sign of this disease. In this report, a woman with acute renal failure subsequent from lupus nephritis is introduced. Case report: 27-year-old woman with no history of systemic disease caused by swelling around the eyes of one month, nausea without vomiting, anorexia, dizziness and a 2-month history of hypertension was admitted. ESR in high range, hypertension and dizziness were

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... observed. Important findings in the laboratory exam were including pre-orbital edema, azotemia, anemia, hematuria, proteinuria, nephropathy normal size, high titers of anti-nuclear antibody, anti-DNA antibodies and lupus anticoagulant was in a field. Renal biopsy was done and the kidney biopsy response was pauci-immune glomerolu, and the patient was treated by pulse corton and hemodialysis. Conclusion: Lupus nephritis as an important complication of systemic lupus erythematosus should be considered, so in patients with acute renal failure, lupus nephritis should be considered, while it isn't usually observed pausi-immune nephritisin renal biopsy in patient with lupus.