Drug induced osteoporosis

Nana Khachidze, Elene Giorgadze
2017 Translational and Clinical Medicine - Georgian Medical Journal  
Osteoporosis, that denotes the bone porosity, is the disease, when the bone mineral density (BMD) is decreased. Bones become porous and fragile, that increase the risk of bone fractures. Bone mass loss develops slowly and progressively. Fractures often develop with no symptoms. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy women (a T-score of ≤ -2.5 SD). Bone cell elements are represented with
more » ... e represented with osteoblasts, osteoclasts, osteocytes and lining cells of small quantity. Osteoblasts are the bone forming cells. Their major functions are the bone matrix synthesis and its following mineralisation. Vitamin D and calcium also participate in the process of mineralisation. Osteoclasts are the bone resorbtion cells. Their main function is the breakdown of old bone and its resorption by lysosomal enzymes. Osteocytes are formed from osteoblasts and promote the maintenance of bone matrix. These cells regulate the activity of modeling and remodeling processes. Osteoporosis represents the result of disbalance of breakdown and synthesis.
doi:10.29088/tcm-gmj.2017.16 fatcat:ue7syvhl6bca7j3lgsevgphaq4