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Respiratory failure is the main cause of mortality and morbidity among ICU patients with coronavirus disease 2019 (COVID-19). In these patients, supplemental oxygen therapy is essential, but there is limited evidence the optimal target. To address this, the ongoing handling oxygenation targets in COVID-19 (HOT-COVID) trial was initiated to investigate the effect of a lower oxygenation target (partial pressure of arterial oxygen (PaO2 ) of 8 kPa) vs a higher oxygenation target (PaO2 of 12 kPa)doi:10.1111/aas.14023 pmid:34951717 fatcat:hnxh6hwznncbroge6zlokh2z5u