Reverse Epidemiology, Obesity and Mortality in Chronic Kidney Disease: Modelling Mortality Expectations Using Energetics

John R. Speakman, Klaas R. Westerterp
2010 Blood Purification  
being fat was predicted to be much larger than that observed in the actual CKD population. Similar results were found for the fat sequestration/underdialysis hypothesis, but in this case the discrepancy was smaller. Discussion: These models tend to support the fat sequestration and underdialysis idea more than the wasting hypothesis. In part (or in whole) this may be because of inadequacies in the model construction which are currently based on rather crude assumptions. Refinement of the models
more » ... may enable better tests between alternative ideas for the obesity paradox.
doi:10.1159/000245642 pmid:20093821 fatcat:yo2riquaubampis3taudqsvk2q