Non-selective beta-adrenergic agonist infusion acutely stimulates the temperature of brown adipose tissue in adult males

Hannah Scotney, Michael Symonds, James Law, Helen Budge, Don Sharkey, Konstantinos Manolopoulos
2015 Endocrine Abstracts  
Results ISO infusion resulted in significant ß-adrenergic mediated increases in heart rate (47 ±4 bpm) peaking at 45 min ( Figure 2a ). ISO infusion resulted in a highly localized increase in local temperature within the supraclavicular region compared to baseline (Δ 0.54 ±0.08°C, P=0.001 [ Figure 2c ,d]) HC resulted in a lesser increase in BAT temperature during ISO infusion (Δ 0.51 ± 0.09°C, P=0.01 [ Figure 2c ,d]). Further, basal BAT temperature is increased in HC compared to saline ( Figure
more » ... 2b ). Conclusions ß-adrenergic stimulation induced dynamic changes in BAT activity that was measurable by IT. This confirms IT as a simple, noninvasive method for assessment of real-time BAT function. Acute hypercortisolaemia resulted in blunting of the adrenergicmediated increase in BAT activity, possibly due to glucocorticoiddependent BAT pre-activation. Future studies should focus on the effects of chronic glucocorticoid excess on human BAT function, and whether tissue-specific inhibition of glucocorticoid activity/generation can contribute to increased BAT thermogenesis.
doi:10.1530/endoabs.38.p219 fatcat:wuyyoez4onfnpn73ysvo57epii