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Deciphering the Therapeutic Resistance in Acute Myeloid Leukemia
International Journal of Molecular Sciences
Acute myeloid leukemia (AML) is a clonal hematopoietic disorder characterized by abnormal proliferation, lack of cellular differentiation, and infiltration of bone marrow, peripheral blood, or other organs. Induction failure and in general resistance to chemotherapeutic agents represent a hindrance for improving survival outcomes in AML. Here, we review the latest insights in AML biology concerning refractoriness to therapies with a specific focus on cytarabine and daunorubicin which stilldoi:10.3390/ijms21228505 pmid:33198085 fatcat:r4lypbcgdrfi5exlo7obydbjqy