Resisting transgenerational epigenetic reprogramming – examples and mechanisms of non-genetic inheritance

Igor Kovalchuk
2013 Non-Genetic Inheritance  
Offspring inherit parental traits in an unaltered manner unless random mutations occur. The manifestation of individual traits depends on the genetic make-up of an organism and on the epigenetic regulation. During the organism's lifespan, numerous changes to its genetic and epigenetic make-up occur and accumulate in different tissues. It is common knowledge that such changes are not passed on to progeny unless they occur in the gametes. Gamete and embryo development is associated with
more » ... ated with reprogramming (removing and reestablishing) of epigenetic marks, and therefore it does not allow a majority of such modifications to be passed on to offspring. It is the escape of reprogramming that largely contributes to the inheritance of acquired epigenetic marks by progeny, thus permitting the establishment of transgenerational epigenetic memory. In this minireview, I will cover several examples of transgenerational memory in animals.
doi:10.2478/ngi-2013-0006 fatcat:p3cnucnhzvcmrnnnwadn3l3564