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Set1-dependent H3K4 methylation becomes critical for DNA replication fork progression in response to changes in S phase dynamics in Saccharomyces cerevisiae
[article]
2020
bioRxiv
pre-print
DNA replication is a highly regulated process that occurs in the context of chromatin structure and is sensitive to several histone post-translational modifications. In Saccharomyces cerevisiae , the histone methylase Set1 is responsible for the transcription-dependent deposition of H3K4 methylation (H3K4me) throughout the genome. Here we show that a combination of a hypomorphic replication mutation ( orc5-1 ) with the absence of Set1 ( set1? ) compromises the progression through S phase, and
doi:10.1101/2020.10.26.355008
fatcat:cilaiwm5anasxalkmsuyrlwhpq