Identification of Self Through Two-Dimensional Chemistry and Synapses

Michael L. Dustin, Shannon K. Bromley, Mark M. Davis, Cheng Zhu
2001 Annual Review of Cell and Developmental Biology  
Cells in the immune and nervous systems communicate through informational synapses. The two-dimensional chemistry underlying the process of synapse formation is beginning to be explored using fluorescence imaging and mechanical techniques. Early analysis of two-dimensional kinetic rates (k on and k off ) and equilibrium constants (K d ) provides a number of biological insights. First, there are two regimes for adhesion-one disordered with slow k on and the other self-ordered with 10 4 -fold
more » ... with 10 4 -fold faster k on . Despite huge variation in two-dimensional k on , the two-dimensional k off is like k off in solution, and two-dimensional k off is more closely related to intrinsic properties of the interaction than the two-dimensional k on . Thus difference in k off can be used to set signaling thresholds. Early signaling complexes are compartmentalized to generate synergistic signaling domains. Immune antigen receptor components have a role in neural synapse editing. This suggests significant parallels in informational synapse formation based on common two-dimensional chemistry and signaling strategies.
doi:10.1146/annurev.cellbio.17.1.133 pmid:11687486 fatcat:pk4ifubsl5gzxd7ncbv2nz7uga