One of the most fundamental questions in biology pertains to how mechano-chemical energy is derived from metabolic fuels. In particular, how oxidation of NADH is linked to ATP synthesis in mitochondrial oxidative phosphorylation (mOxPhos) has been a topic of intense debate. Together, the Peter Mitchell-Paul Boyer proposals for mOxPhos are termed herein as "chemiosmotic rotary ATP synthesis" (or CRAS) model, which was recently defended/advocated by Pedro Silva in Biophysical Chemistry . Over the

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... last two decades, Sunil Nath had questioned some aspects of the CRAS proposal, and made subtle alterations on the roles of Complex V and ions within the reaction scheme, and continues to advocate his framework as "two-ion torsional ATP synthesis" (abbreviated herein as TITAS) model in Biophysical Chemistry . Kelath Murali Manoj had revisited the data on the respiratory machinery's structures/distributions and based on two-decades of evidence-based experimental research in redox enzymology of heme/flavin proteins, had formulated the murburn model for mOxPhos. In this work, the ETC-CRAS hypothesis and its off-shoot, the TITAS proposal, are questioned in the light of the convincing chemicophysical logic provided by the murburn hypothesis.