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A substantial body of carcinogenicity data is available for benzo[a)pyrene (BP), benzo[a)anthracene (BA), and numerous known and potential metabolites of these polycyclic hydrocarbons. The tumor data firmly establish that the 7,8dihydrodiol of BP and the 3,4-dihydrodiol of BA are proximate carcinogens and that the 7,8-diol 9,10-epoxides and the 3,4-diol 1,2-epoxides are ultimate carcinogens derived metabolically from the respective hydrocarbons. The data support the "bay region" theory ofdoi:10.1351/pac197850091033 fatcat:6oc66fqhtrd4bffrkftinierim