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Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice
2008
British Journal of Nutrition
Insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) are found in 35 and 30 % of US adults, respectively. Trans-10, cis-12-conjugated linoleic acid (CLA) has been found to cause both these disorders in several animal models. We hypothesised that IR and NAFLD caused by CLA result from n-3 fatty acid deficiency. Pathogen-free C57BL/6N female mice (aged 8 weeks; n 10) were fed either a control diet or diets containing trans-10, cis-12-CLA (0·5 %) or CLA þ flaxseed oil (FSO) (0·5 %
doi:10.1017/s0007114508027451
pmid:18710604
fatcat:yokiw74hprhgvdoldd3b4bc4sq