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Microfluidics-based biochips, also referred to as lab-on-a-chip, are devices that integrate fluidhandling functions such as sample preparation, analysis, separation, and detection. This emerging technology combines electronics with biology to open new application areas such as point-of-care diagnosis, on-chip DNA analysis, and automated drug discovery. We propose a design automation method for pin-constrained biochips that manipulate nanoliter volumes of discrete droplets on a microfluidicdoi:10.1145/1295231.1295235 fatcat:t6luimczujfqjjysoaoj724kka