Lipoxin A4 As Indicator for Anti-Inflammatory Role of Platelets Rich Plasma (PRP) in Treatment of Chronic Periodontitis
IOSR Journal of Dental and Medical Sciences
chronic periodontitis is pathological multi causes inflammatory disorder and its represent the major cause for teeth losing in adults' patients' .Its affects the surrounding tissues of the teeth leading to pocket formation and alveolar bone loss. Platelets rich plasma (PRP) represents a new modality for treatment of periodontal diseases for its growth factors and anti-inflammatory effects. Lipoxin A4 play a role in inflammation resolution by encourages the apoptosis of neutrophils and act as a
... phils and act as a measurement for inflammatory response to the treatment. The purpose of this study is to evaluate the anti-inflammatory effect of PRP for treatment of chronic periodontitis. Materials and Methods: two groups involved in this study; study group (20 systemically healthy patients with chronic periodontitis) their pockets sites treated with scaling and root planning (SRP) with PRP application. Control group (20 systemically healthy patients with chronic periodontitis) their pockets sites treated with scaling and root planing only. All patients with age ranged from (25-50) years. Patients followed up for one month divided on three visits. Clinical periodontal parameters (Plaque index (PI), Gingival index (GI), Bleeding on probing (BOP), Probing pocket depth(PPD), and Relative attachment level (RAL)) estimation and Blood samples collection were done in the first and third visits for both groups to estimate the platelets count, neutrophils count and Lipoxin A4 concentration. Results: the clinical periodontal parameters for both groups showed reduction in median value between the first and third visits although it's not significant but the results showed more reduction in study group. The neutrophils and platelets count showed reduction in study group between the first and third visits whilein control group the neutrophils count showed reduction in median value but the platelets count showed increased in median value at third visit .there 'was significant difference in median value of Lipoxin A4 concentration level has been reveled in study group than in control group. Conclusion: from the results of this study, it may be concluded that platelets rich plasma have a promising effects as adjunct treatment for SRP in term of reduction the clinical periodontal parameters, decrease the inflammatory response and exert anti-inflammatory effects.