CARCINOGENICITY OF 2-(2-FURYL)-3-(5-NITRO-2-FURYL) ACRYLAMIDE (AF-2) FED TO FEMALE SPRAGUE-DAWLEY RATS

Samuel M. COHEN, Masataka ICHIKAWA, George T. BRYAN
1977 GANN  
The carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) was investigated by administering it orally to Sprague-Dawley female weanling rats in a grain diet at a dose of 0.2% for 46 weeks, followed by 20 weeks of unmedicated control diet. The total mean cumulative dose of AF-2 was 10.1g (41.6 mmol) per rat during the 46 weeks of the experiment. Weight gain of rats fed AF-2 was comparable to that of unmedicated control rats. Survival of rats fed AF-2 was 52 ± 12 (SD) weeks compared
more » ... to 65 ± 5 weeks for the unmedicated controls (Pく *2 Honjo 2-2-1 , Kumamoto 860 (市川 正 孝).
doi:10.20772/cancersci1959.68.4_473 fatcat:4ncpco7i4reaviwe2gjvhz7quu