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The linkage of vascular genes to specific functions will lead to a better understanding of cardiovascular pathophysiology. We developed an experimental model that enables the introduction of one or multiple gene(s) into vascular smooth muscle cells (VSMCs) of isolated resistance arteries. Exposure of the arteries to a green fluorescent protein (GFP)-encoding plasmid in combination with the transfectant Effectene ® for 20 h resulted in the expression of GFP in virtually all VSMCs in the arterialdoi:10.1159/000072830 pmid:12913332 fatcat:x5exbek4wvc35exy54xhe473se