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Accurate evaluation of the effect of point mutations on protein function is essential to assessing the genesis and prognosis of many inherited diseases and cancer types. Currently, a wealth of computational tools has been developed for pathogenicity prediction. Two major types of data are used to this aim: sequence conservation/ evolution and structural properties. Here, we demonstrate in a systematic way that another determinant of the functional impact of missense variants is the protein'sdoi:10.1016/j.bpj.2017.11.1291 fatcat:x7v4nnco5jbitglocswsy4btee