Immunogenic and Protective Properties of Recombinant Proteins Based on Meningococcal Iga1 Protease

Zinchenko AA, Alliluev AP, Serova OP, Gordeeva EA, Zhigis LS, Zueva VS, Razgulyaeva OA, Melikhova TD, Nokel EA, Drozhzhina E Yu, Kotelnikova OV, Rumsh LD
2015 Journal of Meningitis  
Recombinant proteins (M1K2-N963-LEH6, MA28-N963-LEH6 and ME135-H328-LEH6) have been created on the basis of the genome sequence of IgA1 protease of N. meningitidis serogroup B strain H44/76. It is revealed that, similarly to the native enzyme isolated earlier from N. meningitidis serogroup A strain A208, these proteins induce formation of animal protection against the infection with the virulent strain of meningococcus serogroup B. It is shown that these compounds are promising as a basis for a polyvalent anti-meningococcal vaccine.
doi:10.4172/2572-2050.1000102 fatcat:75wgxtjft5cetmovclqohkrviq