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PHF23 negatively regulates the autophagy of chondrocytes in osteoarthritis
2020
Life Sciences
Osteoarthritis (OA) is the main cause of disability and joint replacement surgery in the elderly. As a crucial cell survival mechanism, autophagy has been reported to decrease in OA. PHF23 is a new autophagy inhibitor which was first reported by us previously. This study aimed to explore the anti-autophagic mechanism of PHF23 to make it a possible therapeutic target of OA. Lentiviral vectors specific to PHF23 were used on chondrocytes (C28/I2) to establish PHF23 overexpressed or knockdown
doi:10.1016/j.lfs.2020.117750
pmid:32380078
fatcat:mgnclzzllvdcbp3ofhpb4gy4cm