新規人工聴覚器(人工聴覚上皮)の開発
Development of novel artificial hearing device (artificial auditory epithelium)

Juichi Ito
2017 Otology Japan  
Inner ear disorders such as sensorineural hearing loss are incurable in some occasion by conventional therapeutic strategies. New therapeutic strategies for protection or recover of inner ear function are therefore to be investigated. The aim of this project is to investigate a newly-invented artificial auditory epithelium which is implantable in the inner ear. We have developed a device, which consists of a 40-micrometer-thick piezoelectric material. Piezoelectric material was fixed in a
more » ... oid-shape, which mimics the shape of the basilar membrane so that it will possess frequency characteristics. Pure tone was given to the prototype in the air at frequencies from 3 kHz to 20 kHz at 60 dB SPL. Oscillations of the prototype were detected and voltages produced by the prototype were measured for each electrode. The device can imitate the functions of sensory epithelia of the cochlea and transform vibratory movements into electric signals with frequency characteristics. This device can generate electrical potentials in response to sound stimuli that are able to induce auditory brain stem responses in deafened guinea pigs, indicating its capacity to mimic basilar membrane function. Artificial auditory epithelium will become an effective tool for the treatment of highly hearing-impaired patients.
doi:10.11289/otoljpn.27.671 fatcat:jwep6uenbnaktehyd4tpkb3ede