Ziqi Ye,1,* Hongying Zhao,2,* Wuyuan Zhou,3 Tao Ye,4 Chong Geng,4 Xiaofeng Li,5 Lei Yuan,6 Mingyu Du,7 Heng Xu,8 Qiang Wang4 1The First Clinical Medical College, Graduate School, Nanjing Medical University, Nanjing, Jiangsu 210000, People's Republic of China; 2Medical Oncology, Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221005, People's Republic of China; 3Department of Hepatopancreatobillary Surgery, Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221005, People's Republic of China; 4Department of

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... on Oncology, Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221005, People's Republic of China; 5Department of Radiology, Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221005, People's Republic of China; 6Department of Intervention, Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221005, People's Republic of China; 7Department of Radiation Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210000, People's Republic of China; 8Laboratory of Pharmaceutical Chemistry, Jiangsu Province Institute of Materia Medica, Nanjing Tech University, Nanjing, Jiangsu 210000, People's Republic of China*These authors contributed equally to this workCorrespondence: Qiang WangDepartment of Radiation Oncology, Xuzhou Cancer Hospital, No. 131, Huancheng Road, Xuzhou, Jiangsu 210005, People's Republic of China, Email doctorwang618@126.comAim: This study was designed to investigate the relationships of serum matrix metalloproteinase 9 (MMP-9) level and treatment response in esophageal squamous cell carcinoma (ESCC) patients treated with chemotherapy or concurrent radiotherapy.Methods: Blood samples from ESCC patients after chemotherapy or concurrent radiotherapy were collected at four different intervals. Serum MMP-9 was determined via Luminex assay in 134 patients with chemotherapy, 73 patients with concurrent radiotherapy, and 183 healthy controls.Results: Serum MMP-9 level was significantly higher in patients with ESCC than in healthy controls (P < 0.001). Compared [...]