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Single dose of BNT162b2 mRNA vaccine against SARS-CoV-2 induces high frequency of neutralising antibody and polyfunctional T-cell responses in patients with myeloproliferative neoplasms [article]

Patrick Harrington, Hugues de Lavallade, Katie Doores, Amy O'Reilly, Jeffrey Seow, Carl Graham, Thomas Lechmere, Deepti Radia, Richard Dillon, Yogita Shanmugharaj, Andreas Espehana, Claire Woodley (+8 others)
2021 medRxiv   pre-print

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https://web.archive.org/web/20210717022634/https://www.medrxiv.org/content/medrxiv/early/2021/05/11/2021.04.27.21256096.full.pdf

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Encouraging results have been observed from initial studies evaluating vaccines targeting the novel beta coronavirus which causes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, concerns have been raised around the efficacy of these vaccines in immunosuppressed populations, including patients with haematological malignancy. Myeloproliferative neoplasms (MPN), in particular myelofibrosis (MF), are associated with heterogenous immune defects which are influenced by patient
more » ... ge, disease subtype and the use of cytoreductive therapies. Patients with a WHO defined diagnosis of an MPN presenting to our clinic were recruited following first injection of 30μg BNT162b2. A positive anti-S IgG ELISA was seen in 76.1% (16) of patients following vaccination with positive neutralising antibodies detected in 85.7% (18) of patients. A memory T cell response was observed in 80% (16) of patients, with a CD4+ T cell response in 75% (15) and a CD8+ T cell response in 35% (7). These results, for the first time, provide some reassurance regarding the initial immune response to the BNT162b2 vaccine amongst patients with MPN, with response rates similar to that observed in the general population.
doi:10.1101/2021.04.27.21256096 fatcat:27iluk4fhndadotyzkozvyc7om
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Patrick Harrington, Hugues de Lavallade, Katie Doores, Amy O'Reilly, Jeffrey Seow, Carl Graham, Thomas Lechmere, Deepti Radia, Richard Dillon, Yogita Shanmugharaj, Andreas Espehana, Claire Woodley, Jamie Saunders, Natalia Curto Garcia, Jennifer O'Sullivan, Kavita Raj, Shahram Kordasti, Michael H Malim, Claire N Harrison, Donal McLornan. "Single dose of BNT162b2 mRNA vaccine against SARS-CoV-2 induces high frequency of neutralising antibody and polyfunctional T-cell responses in patients with myeloproliferative neoplasms." medRxiv (2021)