Subclinical Cushing's Disease Accompanied by Malignant Hypertension and Diabetes Mellitus

Takashi NAGAI, Makoto IMAMURA, Shuuzou MISUMI, Masatomo MORI
2002 Internal medicine (Tokyo. 1992)  
A 53-year-old woman was admitted because of hypertension and diabetes inellitus. Elevated diastolic blood pressure, hypertensive retinopathy and renal dysfunction indicated malignant hypertension. Adrenocorticotropic hormone (ACTH)and cortisol levels were high although there were no Cushingoid features.One mgdexamethasone administration decreased neither ACTHnor cortisol levels. Brain magnetic resonance imaging revealed a left pituitary tumor (7 mmx 6 mm).Uponremoval, the tumor showed positive
more » ... or showed positive ACTHstaining by immnohistochemistry, and was diagnosed as pituitary ACTH-secreting adenoma (Cushing's disease). Her blood pressure, renal function, blood glucose and hormone levels subsequently improved. Malignant hypertension and deteriorated diabetes mellitus mayhave been due to subclinical Cushing's disease. (Intrenal Medicine 41: 566-570, 2002)
doi:10.2169/internalmedicine.41.566 fatcat:jsfw7vgiyjcafa5lrx7bpmjxma