We present two cases of non-capsulated Haemophilus influenzae hepatobiliary infection and review the literature. Such cases are rare, and prior to routine immunization against H. influenzae serotype b invasive Haemophilus disease was largely caused by capsulated strains. The epidemiology of invasive Haemophilus infections has changed and the number of cases of intra-abdominal and hepatobiliary infection may be underestimated due to current microbiological processing practices. Abbreviations:

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... , common bile duct; CT, computed tomography; Hib, Haemophilus influenzae serotype b; NTHi, non-typable Haemophilus influenzae.