Evaluation of response to chemotherapy in locally advanced breast cancer with mri, importance of lesion size and adc value, and association with ki-67 index

Cengiz A, Altunkeser A, Eryilmaz MA, Tolu I, Kucukosmanoglu I
2018 Radiology and Diagnostic Imaging  
Contrast-enhanced and diffusion-weighted magnetic resonance imaging is one of the most sensitive imaging techniques used to diagnose and manage breast cancer. Neoadjuvant chemotherapy is applied to the patients before surgery in locally advanced breast cancer. To investigate the role of contrast-enhanced and diffusion-weighted magnetic resonance imaging in evaluating neoadjuvant chemotherapy response in locally advanced breast cancer, we compared the pre-and posttreatment lesion size and ADC
more » ... ion size and ADC values and evaluated their relationship with the Ki-67 index. Material and Method: In the scope of the study, 39 female patients with locally advanced breast cancer who underwent neoadjuvant chemotherapy and surgical operation between 2010 and 2017 were retrospectively reviewed. Lesion size was determined from contrasted magnetic resonance imaging before and after neoadjuvant chemotherapy, ADC value was measured from diffusion weighted images and these were compared. The size measured after neoadjuvant chemotherapy was compared with the surgically removed tumor size. The relationship between tumor size and ADC value before the treatment and Ki-67 index was investigated. Result: Lesion size which was measured with magnetic resonance imaging after neoadjuvant chemotherapy was correlated with surgically removed tumor size. Significant reduction in tumor volume and increase in ADC value were observed with treatment (p< 0.001). Pretreatment ADC values of tumors with high Ki-67 index were low (p = 0.031), while ADC values of surgically removed large lesions were high (p< 0.001). Conclusion: Tumor size obtained with magnetic resonance imaging and ADC value are important parameters to follow response to neoadjuvant chemotherapy in locally advanced breast cancer. It may also guide treatment management if used combined with Ki-67 index. Cengiz A (2018) Evaluation of response to chemotherapy in locally advanced breast cancer with mri, importance of lesion size and adc value, and association with ki-67 index Volume 2(4): 2-4
doi:10.15761/rdi.1000137 fatcat:54dtg5yxevg3ha5gpfuaz7a3uq