Cancerous diseases and diseases resulting from bacteria and fungi are some of the pressures that humans face. Therefore, the development of biomaterials that are resistant to cancerous diseases, bacteria, and fungi has become one of the requirements of the medical field to extend the life of the biomaterial and fight pathogens after implanting these materials inside the human body. One of the important biomaterials used in the field of orthopedics is hydroxyapatite. In this research, Nano

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... tuted hydroxyapatite was prepared by the wet precipitation method, including replacing 5% of the calcium ions with neodymium, cerium, magnesium, and zinc ions in cationic substitution. Many tests were carried out to characterize the prepared material. The biological properties were evaluated by examining the resistance of the substituted hydroxyapatite to bacteria and fungi, in addition to testing the effect of the material on normal cells and bone cancer cells. The results showed a new structure of hydroxyapatite after the substitution process and a significant improvement in the biological properties of the prepared biomaterial compared to other researches.