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Sequence conservation, relative isoform frequencies, and nonsense-mediated decay in evolutionarily conserved alternative splicing
2005
Proceedings of the National Academy of Sciences of the United States of America
Studies of expressed sequence tag data sets have revealed large numbers of splicing variants for human genes, but it remains challenging to distinguish functionally important variants from aberrant splicing, clarify the nature of the alternative functions, and understand the signals that regulate splicing choices. To help address these issues, we have constructed and analyzed a large data set of 1,478 exon-skipping alternative splicing (AS) variants evolutionarily conserved in human and mouse.
doi:10.1073/pnas.0506139102
pmid:16123126
pmcid:PMC1192826
fatcat:xf7hkn4kyrdwxfzwi4nmk6dlbu