Internet Archive Scholar

Prebiotic Fiber Supplementation Differentially Affects Metabolic Parameters Regulating Obesity in Rats Raised in Small versus Large Litters [article]

Danielle Tenley Reid, University Of Calgary, University Of Calgary, Raylene Reimer
2011

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (2.4 MB)
https://web.archive.org/web/20220119193131/https://prism.ucalgary.ca/bitstream/handle/1880/48391/2011_Reid_MSc.pdf;jsessionid=4B3443EE1CD48A6022F0BEF9DC6B0BF2?sequence=1

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL. The file type is application/pdf.

The objective of this study was to examine weight gain and satiety hormone levels in rats raised in small versus large litters and weaned onto control or oligofructose (OFS)-enriched diets. Small litters (SL, 3 pups) and normal litters (NL, 12 pups) of male Sprague-Dawley rats were fed 1 of 4 diets from 3 to 19 weeks of age: 1) Normal Energy density (NE), 2) NE + 10% OFS, 3) High Energy density (HE), 4) HE + OFS. At weaning, SL body weight was higher than NL. OFS significantly reduced body
more » ... t independent of litter size. OFS significantly reduced glycemia in all groups except SL-NE rats and increased glucagon-like peptide-1 (GLP-1) in all groups except for NL-NE rats. Satiety hormone gene expression was differentially modified in SL and NL rats fed OFS. These results indicate that prebiotic fiber feeding was able to mitigate some aspects of programmed obesity risk.
doi:10.11575/prism/23811 fatcat:7j4ssjd6xrfvtducwb2lgy6uxy
Citation

Danielle Tenley Reid, University Of Calgary, University Of Calgary, Raylene Reimer. "Prebiotic Fiber Supplementation Differentially Affects Metabolic Parameters Regulating Obesity in Rats Raised in Small versus Large Litters." (2011)