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Procedures for investigating biomedical implant surfaces and biological cell / surface interactions in plan-view and cross-sectional geometries are described. Ultramicrotomy, FIBSEM and cryogenic-FIBSEM techniques, as developed for the controlled cross-sectioning of human osteoblasts on Ti substrates for TEM investigation, are compared.doi:10.1088/1742-6596/241/1/012019 fatcat:xmliubyc5nfnllsz5gboxzmjri