Biotherapy for and protection against gastrointestinal pathogenic infections via action of probiotic bacteria

Mongkol Thirabunyanon
2011 Maejo Int. J. Sci. Technol   unpublished
The microbiota in the human intestine play an important function in human health and disease. Gastrointestinal infections by foodborne pathogens are a main cause of morbidity and mortality worldwide. Such infections can be caused by contaminated foods or other sources which come in contact with human intestinal epithelial cells. In recent years, probiotics have been recommended as alternative biotherapeutic agents against intestinal pathogenic infections. Two genera of probiotics, Lactobacillus
more » ... tics, Lactobacillus and Bifidobacterium, are commercially valuable applications, several forms of which are available as capsules or in functional food products such as yogurt, fermented juices and sausages. Probiotics protect against gastrointestinal pathogenic infection via several mechanisms. These include production of antimicrobial substances, competition for nutrient substrates, competitive exclusion, enhancement of intestinal barrier function, and immunomodulation. Probiotic bacteria have been documented as being effective in biotherapeutic applications against gastrointestinal pathogens, e.g. Helicobacter pylori, Salmonella, Escherichia coli, Listeria monocytogenes, and rotaviruses. This alternative therapeutic application of probiotics to protect against gastrointestinal pathogenic infections may be of great importance for future medicinal use.