Protective Effects of Vaccinium Uliginosum Extracts on Rat Retina Against Microwave- induced Damage
Objective To study the protective effect of Vaccinium Uliginosum (VU) extracts on rat retina against microwave radiation induced injury. Methods The rats were randomized into 3 groups (12 in each) and treated as follows: group 1: no irradiation; group 2: irradiation without administration; group 3: irradiation with administration in advance. After administration to group 3 with VU extracts for 1 week, group 2 and 3 were irradiated. 24 hours later, all the rats were recorded with
... phy (ERG). Half of each group were performed with pathological examination, and the rest were performed with biochemical detection [superoxide dismutase (SOD) and glutathione peroxidase (GPx)]. Results 1.Compared with group 2, both of group 1 and group 3 showed a significant increase in a-wave ERG amplitudes in scotopic and photopic conditions, and the b-wave amplitude of group 3 was significantly higher than group 2 but lower than group 1 in photopic condition. 2. The thickness of outer nuclear layer (ONL) in group 2 was thicker than group 1 and group 3; The cell density of inner nuclear layer (INL) and the ganglion cells layer (GCL) both showed that group 3 was more than group 2 but less than group 1. 3. The SOD activitiy in group 2 was lower than group 1 and 3. The GPx activitiy in group 3 was lower than group 1, but higher than group 2. Conclusions VU extracts can protect rat retina against microwave-induced damage. And these results may provide a base for exploring the possible preventive and therapeutic measures.