Template synthesis of macrocyclic complexes of Co(II), Ni(II), Cu(II), Zn(II) and Cd(II): Spectroscopic, antibacterial and antifungal studies

Dharam Singh, Vandna Malik, Ramesh Kumar, Krishan Kumar
2010 Journal of the Serbian Chemical Society  
A new series of macrocyclic complexes of the type [M(C 17 H 14 N 4 O 2 )X 2 ], where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and X = Cl -, NO 3 -, CH 3 COOwas synthesized by the condensation reaction of malonyldihydrazide with benzil in the presence of divalent metal ions. The complexes were characterized with the aid of elemental analyses, conductance measurements, magnetic susceptibilities, electronic, NMR and infrared spectral studies. On the basis of these studies, a six coordinate
more » ... ix coordinate distorted octahedral geometry, in which two nitrogen and two carbonyl oxygen atoms are suitably placed for coordination towards metal ion, is proposed for all the complexes. The complexes were tested for their in vitro antibacterial activity and antifungal activities. The minimum inhibitory concentration shown by these complexes were compared with the minimum inhibitory concentration shown by standard drugs.
doi:10.2298/jsc090901050s fatcat:ypsyifbwzvfeddnbm2gkw3gldm