A mathematical model for within-host Toxoplasma gondii invasion dynamics

Adam Sullivan, Folashade Agusto, Sharon Bewick, Chunlei Su, Suzanne Lenhart, Xiaopeng Zhao
2012 Mathematical Biosciences and Engineering  
Toxoplasma gondii (T. gondii ) is a protozoan parasite that infects a wide range of intermediate hosts, including all mammals and birds. Up to 20% of the human population in the US and 30% in the world are chronically infected. This paper presents a mathematical model to describe intra-host dynamics of T. gondii infection. The model considers the invasion process, egress kinetics, interconversion between fast-replicating tachyzoite stage and slowly replicating bradyzoite stage, as well as the
more » ... e, as well as the host's immune response. Analytical and numerical studies of the model can help to understand the influences of various parameters to the transient and steady-state dynamics of the disease infection.
doi:10.3934/mbe.2012.9.647 pmid:22881030 fatcat:xzm2ltwl2neulgyjma3bgb5alu