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Reconstruction of Cell Lineage Trees in Mice
2008
PLoS ONE
The cell lineage tree of a multicellular organism represents its history of cell divisions from the very first cell, the zygote. A new method for high-resolution reconstruction of parts of such cell lineage trees was recently developed based on phylogenetic analysis of somatic mutations accumulated during normal development of an organism. In this study we apply this method in mice to reconstruct the lineage trees of distinct cell types. We address for the first time basic questions in
doi:10.1371/journal.pone.0001939
pmid:18398465
pmcid:PMC2276688
fatcat:dzbmlqbt4zb4nezfu5ahsxzpaa