W e present the case of a 77-year-old Cambodian woman with a 3-day history of dyspnea on exertion. Physical examination revealed a murmur of mitral regurgitation and decompensated heart failure. The ECG was remarkable for atrial fibrillation with rapid ventricular response. Transthoracic echocardiography showed severe left atrial dilation, a large (5ϫ8 cm) mobile mass attached to the anterior left atrial wall, and several small, mobile aortic masses on the noncoronary cusp of the aortic valve (

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... Figure 1 and online-only Data Supplement Movie I). Three-dimensional transesophageal echocardiography showed a large multilobular mass being displaced by the central jet of moderate to severe mitral regurgitation during systole and prolapse of the mass through the mitral valve during diastole (Figures 2 and 3 and online-only Data Supplement Movies II and III). The atrial mass was attached with a stalk to the anterior atrial wall and appeared lobulated and deformable, consistent with the appearance of a myxoma (online-only Data Supplement Movie IV). The aortic valve masses had multiple frondlike projections, which had an appearance like a sea anemone, with stippling at the edges that arose from the noncoronary aortic valve leaflet (online-Figure 1. Transthoracic echocardiogram shows small, mobile aortic masses on noncoronary cusp of aortic valve (blue arrow) and large mobile mass attached to the anterior left atrial wall (red arrow). LV indicates left ventricle; LA, left atrium; AO, aorta. Figure 2. Three-dimensional transesophageal echocardiogram shows left atrial mass (red arrow). LA indicates left atrium; RV, right ventricle; AO, aorta. Figure 3. Transesophageal echocardiogram shows left atrial mass displaced by central jet of mitral regurgitation during systole. LA indicates left atrium; LV, left ventricle. The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/