Objective: To compare the effect of comprehensive rehabilitation program versus combined garlic therapy and comprehensive rehabilitation program in controlling the clinical manifestations and quality of life in patients with knee osteoarthritis Design: Randomized clinical trial Setting: Outpatient setting Participants: 43 patients with knee osteoarthritis randomized to group I (comprehensive rehabilitation) (n=15) and group II (combined garlic therapy and comprehensive rehabilitation) (n=28).

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... litation) (n=28). Intervention: All patients had diet modification, electrotherapy, resistance and flexibility exercises for legs 3 times weekly for 8 weeks. Group II received garlic capsules 900mg daily with breakfast for 8 weeks. Main Outcome measures: knee pain by visual analogue scale (VAS), Stanford health assessment questionnaire (HAQ), one repetition maximum (1RM) for quadriceps, body mass index (BMI), synovial fluid level of interleukin1β, interleukin 6, tumor necrosis factor ά and selenium.