Fatal Aspergillus Pneumonia in Chronic Granulomatous Disease

James K. Kelly, Alfredo R. Pinto, William A. Whitelaw, Otto P. Rorstad, Thomas J. Bowen, David S. Matheson
1986 American Journal of Clinical Pathology  
A 20-year-old man died from Aspergillus pneumonia three weeks after heavy exposure to grain dust. Lung biopsy and autopsy demonstrated a distinctive form of suppurating granulomatous bronchopneumonia caused by Aspergillus fumigatus, which was the sole agent cultured from the tissue. The liver and lymph nodes contained pigmented lipid histiocytes characteristic of chronic granulomatous disease, and subsequently both of the patient's brothers were found to have X-linked chronic granulomatous
more » ... granulomatous disease. The authors suggest that this morphologic expression of Aspergillus pneumonia should raise a suspicion of neutrophil dysfunction or chronic granulomatous disease. (
doi:10.1093/ajcp/86.2.235 pmid:3526863 fatcat:v4mxsxaqzfg2lohqaz6dxjew4y